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REFERENCES for L-Carnosine

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Use of carnosine as a natural anti-senescence drug for human beings. Biochemistry (Moscow). 2000; 65(7):869-71.

A possible new role for the anti-ageing peptide carnosine. Cell Mol Life Sci. 2000; 57(5):747-53.

Retardation of the senescence of cultured human diploid fibroblasts by carnosine. Exp Cell Res 1994; 212(2):167-75.

Further evidence for the rejuvenating effects of the dipeptide L-carnosine on cultured human diploid fibroblasts. Exp Gerontol. 1999; 34(1):35-45.

Effect of carnosine on age-induced changes in senescence-accelerated mice. J Anti-Aging Med. 1999; 2(4):337-42.

Protein oxidation in aging, disease, and oxidative stress. J Biol Chem. 1997; 272(33):20313-6.

Aging in a dish: age-dependent changes of neuronal survival, protein oxidation, and creatine kinase BB expression in long-term hippocampal cell culture. J Neurosci Res. 1999; 58(2):308-17.

Strategies for the extension of human life span. Perspect Hum Biol. 1995; 1:59-70.

Dramatic aggregation of Alzheimer Ab by Cu(II) is induced by conditions representing physiological acidosis. J Biol Chem. 1998; 273(21):12817-26.


AGEs and their interaction with AGE-receptors in vascular disease and diabetes mellitus. I. The AGE concept. Cardiovascular Research. 1998; 37(3):586-600.

Carnosine protects against excitotoxic cell death independently of effects on reactive oxygen species. Neuroscience. 1999; 94(2):571-7.

Biochemical and physiological evidence that carnosine is an endogenous neuroprotector against free radicals. Cell Mol Neurobiol. 1997; 17(2):259-71.

Carnosine reacts with a glycated protein. Free Radic Biol Med. 2000; 28(10):1564-70.

The antihypertensive hydralazine is an efficient scavenger of acrolein. Redox Rep. 2000; 5(1):47-9.

Diminished susceptibility to proteolysis after protein modification by the lipid peroxidation product malondialdehyde: inhibitory role for crosslinked and noncrosslinked adducted proteins. Arch Biochem Biophys. 1997; 340(2):331-7.

Butterfield DA. Alzheimer's b-amyloid peptide and free radical oxidative stress. Gilbert DL and Colton CA, editors. Reactive oxygen species in biological systems: an interdisciplinary approach. New York, 1999. Pp. 609-638.

Aging- and oxygen-induced modifications in brain biochemistry and behavior. Ann NY Acad Sci. 1994; 738:44-53.

Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spatial memory by chronic administration of the spin-trapping compound N-tert-butyl-alpha phenylnitrone. Proc Natl Acad Sci USA. 1991; 88(9):3633-6.

Aqueous dissolution of Alzheimer's disease Ab amyloid deposits by biometal depletion. J Biol Chem. 1999; 274(33):23223-8.

The role of excitotoxicity in neurodegenerative disease: implications for therapy. Pharmacol Ther. 1999; 81(3):163-221.

Age-related losses of cognitive function and motor skills in mice are associated with oxidative protein damage in the brain. Proc Natl Acad Sci USA. 1996; 93(10):4765-9.

Effect of antioxidants on hyperoxia-induced chromosomal breakage in Chinese hamster ovary cells: protection by carnosine. Mutagenesis. 1991; 6(4):313-8.

Superoxide-scavenging activity of carnosine in the presence of copper and zinc ions. Biochemistry (Moscow). 1987; 52(7 Part 2):1051-4.

Carnosine prevents activation of free-radical lipid oxidation during stress. Bull Exp Biol Med. 1989; 107(2):148-152.

The limited in vitro lifetime of human diploid cell strains. Exp Cell Res. 1965; 37:614-36.

The serial cultivation of human diploid cell strains. Exp Cell Res. 1961; 25:585-621.

Carnosine protects proteins against methylglyoxal-mediated modifications. Biochem Biophys Res Commun. 1998; 248(1):28-32.

Non-enzymatic glycosylation of the dipeptide L-carnosine, a potential anti-protein-cross-linking agent. FEBS Lett. 1995; 371(1):81-5.

Protective effects of carnosine against malondialdehyde-induced toxicity towards cultured rat brain endothelial cells. Neurosci Lett. 1997; 238(3):135-8.

Pluripotent protective effects of carnosine, a naturally occurring dipeptide. Ann NY Acad Sci. 1998; 854:37-53.

Endogenous mechanisms of neuroprotection: role of zinc, copper, and carnosine. Brain Res. 2000; 852(1):56-61.

Cu(II) potentiation of alzheimer Ab neurotoxicity. Correlation with cell-free hydrogen peroxide production and metal reduction. J Biol Chem. 1999; 274(52):37111-6.

Carnosine stimulates vimentin expression in cultured rat fibroblasts. Cell Struct Funct. 1999; 24(2):79-87.

Carnosine sustains the retention of cell morphology in continuous fibroblast culture subjected to nutritional insult. Biochem Biophys Res Commun. 1996; 223(2):278-82.

Analysis of a form of oxidative DNA damage, 8-hydroxy-2'-deoxyguanosine, as a marker of cellular oxidative stress during carcinogenesis. Mutat Res. 1997; 387(3):147-63.


A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide. J Neurochem. 1997; 68(1):255-64.

Influence of advanced glycation end-products and AGE-inhibitors on nucleation-dependent polymerization of beta-amyloid peptide. Biochim Biophys Acta. 1997; 1360(1):17-29.

Alzheimer's disease--synergistic effects of glucose deficit, oxidative stress and advanced glycation endproducts. Journal of Neural Transmission. 1998; 105(4-5):439-61.

 Action of carnosine and beta-alanine on wound healing. Surgery. 1986; 100(5):815-21.

Toxic effects of beta-amyloid(25-35) on immortalised rat brain endothelial cell: protection by carnosine, homocarnosine and beta-alanine. Neurosci Lett. 1998; 242(2):105-8.

Carnosine: its properties, functions and potential therapeutic applications. Mol Aspects Med. 1992; 13(5):379-444.

Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosis. Circ Res. 1999; 84(5):489-97.

Cytochemical demonstration of oxidative damage in Alzheimer disease by immunochemical enhancement of the carbonyl reaction with 2,4-dinitrophenylhydrazine. J Histochem Cytochem. 1998; 46(6):731-5.

Protein oxidation and aging. Science. 1992; 257(5074):1220-4.

Protein oxidation. Ann NY Acad Sci. 2000; 899:191-208.

Concentrations of free carnosine (a putative membrane-protective antioxidant) in human muscle biopsies and rat muscles. Arch Gerontol Geriatr. 1999. 29: 107-113.

Carnosine: an endogenous neuroprotector in the ischemic brain. Cell Mol Neurobiol. 1999; 19(1):45-56.

b-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature. 1996; 380(6570):168-71.

Cerebromicrovascular pathology in Alzheimer's disease compared to normal aging. Gerontology. 1997; 43(1-2):26-43.

Effects of carnosine on the development of rat sponge-induced granulation tissue. II. Histoautoradiographic observations on collagen biosynthesis. Cell Mol Biol. 1983; 29(1):1-9.

RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease. Nature. 1996; 382(6593):685-91.

Carnosine is a novel peptide modulator of intracellular calcium and contractility in cardiac cells. Am J Physiol 1997; 272(1 Pt 2):H462-8.